Well it is a matter of your own preference. However, the two programs do not interfere between each other so you can perform all the operations smoothly. However, I will suggest you to be an HP Support Assistant as it’s easy to keep a check on its regular updates and you can easily resolve your printer related issues easily with the HP support assistant. Rest is up to your choice, if you want to take a break from the HP support assistant you can. Make sure you keep an eye on the updates provided by windows and check for printer updates on the official website every once in a while.